Aldosterone Affecting the Cell
Describe the Signal
Is the signal molecule a hormone, neurotransmitter, paracrine signal, cell surface receptor, or gas molecule? Where did the signal originate? How was it conveyed to the receiving cell? What is the half-life of the signal (how long does it persist once released)? Is it degraded? Recycled? Does the signal pass through the cell membrane? Does it interact only at the surface of the cell? (Aldosterone Affecting the Cell)
Describe the Receptor
Describe the general size and structure of the receptor which binds to your signal. Which particular areas of the receptor bind to the signal molecule? Are there other key functional portions of the receptor protein? Some receptors are true transmembrane proteins, while others are cytosolic proteins that bind to signals which have been transported into the cell. Which type is yours?
Describe the Cascade of Events that Follow Receptor Signal Interaction
In general, the cellular response that occurs downstream of receptor-signal binding will involve a series of membrane-tethered and cytosolic proteins. Often the proteins are modified through phosphorylation or dephosphorylation, which alters their interactions and location within the cell. In some signal transduction pathways, small molecules called second messengers (such as calcium or cyclic AMP) are generated. Be sure to provide a good step by step description of this process. Include any points where your pathway intersects with a related pathway. For example, two different receptors may generate the same type of second messenger molecule.
Overall Effects on the Cell
What is the overall effect on the cell? Does the pathway alter growth, migration, differentiation, survival, etc.? Does this pathway alter gene expression in any way? How quickly do the effects occur and how long will they last?
Given the effects on your cell and pathway of interest, what is the overall significance of this pathway to the survival of the organism? What is the significance of this pathway for health and disease? Are there any therapeutics that affect this pathway?
Resources – Best Sources to find your reference diagram
NCBI bookshelf – this searches several online textbooks
Title; Aldosterone Affecting the Cell
Length; 10 pages (2750 words)